Paris, France, June 30^th, 2023 – POLYGON Therapeutics, a biotechnology company, is thrilled to announce the establishment of an earlyResearch and Development (R&D) unit in partnership with the ParisCardiovascular Research Center (PARCC). POLYGON Therapeutics was created fromthe work of Prof. Hafid AIT-OUFELLA, who heads Team 5 “Immuno-metabolicmechanisms of cardiovascular diseases” in this research center. Thiscollaboration brings together the expertise of both organizations to acceleratethe development of innovative therapies that address unmet medical needs in thefield of cardiovascular health.

The newly established early R&D unit, located within the PARCC research center, will serve as a hub for POLYGON's cutting-edge scientific research and discovery efforts. By leveraging PARCC's renowned infrastructure, resources, and collaborative environment, POLYGON aims to enhance its capabilities in cardiovascular disease research and accelerate the translation of scientific discoveries into potential breakthrough therapies.

"We are delighted to join forces withPARCC, a distinguished leading research center in cardiovascular diseases, to establish our early R&D unit", said Mohamed ABOU ALI, Chief Executive Officer at POLYGON Therapeutics. "This collaboration represents asignificant step forward in our mission to revolutionize cardiovascular diseasetreatments and improve patient outcomes."
Prof. Hafid AIT-OUFELLA, Chief Scientific Officer at POLYGON Therapeutics added “It is very exciting to see the potential clinical application of ourexperimental research come to fruition.”

The PARCC research center, a globally recognized institution dedicated to cardiovascular disease research, will provide POLYGON with access to state-of-the-art laboratories, cutting-edge technologies, and a network of renowned cardiovascular researchers and clinicians. This partnership will foster collaboration and knowledge sharing, driving innovation and the development of novel therapeutic approaches.

Chantal BOULANGER, Director of PARCC, expressed enthusiasm about the collaboration: "We are excited to welcome POLYGON Therapeutics into our research center. This partnership aligns with our mission to bridge the gap between basic science and clinical applications, and together, we can make significant strides in the field of cardiovascular disease research."

POLYGON Therapeutics' early R&D unit willfocus on the discovery and development of groundbreaking treatments for a range of cardiovascular diseases, including post-ischemic heart failure, atherosclerosis, and other immune related conditions. The company's innovative approach combines advanced technologies, such as biotherapies, precision medicine, and targeted cytotoxic immunity, to develop therapies that are more effective, personalized, and ultimately capable of improving patient outcomes.

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About POLYGON Therapeutics:

POLYGON Therapeutics is a French biotech company developing innovative drugs to treat patients suffering from cardiovascular diseases and acute immune disorders. Its main drug is afirst-in-class monoclonal antibody, PLG-101.

Cardiovascular Diseases (CVDs) are the number 1cause of death globally: in recent times, 18 million people have died annually from CVDs, representing 31% of all global deaths. Among these deaths, 85% are due to heart attacks and strokes. Despite a better management of risk factors (e.g. hypercholesterolemia and hypertension) and significant progress in CVD care, new therapeutic approaches remain untapped.

POLYGON’s first therapeutic solution, PLG-101,aims to target a specific immune response happening during myocardial infarction to enhance post-ischemic cardiac remodeling. It has already shown successful results on preclinical models. Potential in other cardiovascular indications has been highlighted.

https://www.polygon.care/

About PARCC INSERM:

The Paris Cardiovascular Research Center(PARCC) is a world renowned research center specialized in cardiovascular diseases. PARCC's mission is to advance scientific knowledge, bridge the gap between basic science and clinical applications, and develop innovative therapies to combat cardiovascular disorders.

http://parcc.inserm.fr